Cassine (Piedmontese: Cassèine) is a town and comune of the Province of Alessandria in the Italian region Piedmont. It is located 21 km southwest of the town Alessandria on the left of the lower course of the Bormida in the Alto Monferrato Acquese. The place lies partly in the hills, where the ancient nucleus of the settlement formed, and partly on the plain. Its economic character is agricultural: the hills are rich in vineyards which and the wines Moscato d’Asti, Barbera and Freisa are produced as well as grappa.